Analytical Data
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基因名
ILK-2
- Application
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别名
59 kDa serine/threonine protein kinase; 59 kDa serine/threonine-protein kinase; DKFZp686F1765 ; Epididymis secretory protein Li 28; HEL S 28; ILK 1; ILK 2; ILK; ILK-1; ILK-2; ILK_HUMAN; ILK1; ILK2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13418
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表达区间
1-452aa
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氨基酸序列
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK
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分子量
51.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ILK-2 (Integrin-linked kinase-2) is a pivotal serine/threonine kinase that plays a crucial role in various cellular processes, including cell adhesion, migration, and survival. Its significance has gained attention due to its implications in several pathological conditions, such as cancer progression and cardiovascular diseases. Research has demonstrated that ILK-2 is involved in the signaling pathways activated by integrins, which are vital for cell-extracellular matrix interactions. The study of ILK-2 recombinant proteins has emerged as a valuable approach to elucidate its functional roles and molecular mechanisms. By generating and purifying ILK-2 recombinant proteins, researchers aim to investigate its enzymatic activity, downstream signaling partners, and influence on cellular behaviors. Furthermore, understanding the structural characteristics of ILK-2 through crystallography and biophysical methods can shed light on how it interacts with other proteins and regulates cellular functions. Investigations using ILK-2 recombinant proteins not only advance our fundamental knowledge of cellular signaling but also hold potential for therapeutic applications. Targeting ILK-2's activity could lead to the development of novel treatments for diseases where its dysregulation is a contributing factor. As such, ILK-2 remains a focal point in molecular biology and biochemistry, with ongoing studies striving to unravel its complexities and therapeutic potential.
