Analytical Data
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Gene name
GLUT4
- Application
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Alternative Names
GLUT4；GLUT4；Solute carrier family 2. facilitated glucose transporter member 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14672
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Expression Region
1-509aa
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AA Sequence
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQK VIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIG IISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSG LTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTAS LWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGW ADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRR TLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPG PIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVF LLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTEL EYLGPDEND
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GLUT4, or glucose transporter type 4, is a pivotal protein responsible for the insulin-regulated uptake of glucose in adipose tissue and skeletal muscle, playing a crucial role in glucose homeostasis and metabolic health. Impaired GLUT4 translocation to the plasma membrane is closely associated with insulin resistance, a key feature of type 2 diabetes and obesity. Given the increasing prevalence of these metabolic disorders globally, understanding GLUT4 dynamics has become increasingly important. Researchers have focused on recombinant GLUT4 proteins to elucidate the mechanisms governing its transport and function. These recombinant proteins provide a valuable tool in dissecting GLUT4's regulatory pathways, post-translational modifications, and interactions with other cellular components. Moreover, insights gained from these studies may pave the way for the development of novel therapeutic strategies aimed at enhancing GLUT4 activity and improving insulin sensitivity. Therefore, the investigation of GLUT4 recombinant proteins is vital for advancing our understanding of metabolic diseases and identifying potential interventions to combat the global diabetes epidemic.
