Analytical Data
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Gene name
ICA1L
- Application
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Alternative Names
ICA1L; ALS2CR14; ALS2CR15; Islet cell autoantigen 1-like protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NDH6
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Expression Region
1-482aa
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AA Sequence
MDSFGQPRPEDNQSVVRRMQKKYWKTKQVFIKATGKKEDEHLVASDAELDAKLEVFHSVQETCTELLKIIEKYQLRLNVISEEENELGLFLKFQAERDATQAGKMMDATGKALCSSAKQRLALCTPLSRLKQEVATFSQRAVSDTLMTINRMEQARTEYRGALLWMKDVSQELDPDTLKQMEKFRKVQMQVRNSKASFDKLKMDVCQKVDLLGASRCNMLSHSLTTYQRTLLGFWKKTARMMSQIHEACIGFHPYDFVALKQLQDTPSKISEDNKDEQIGGFLTEQLNKLVLSDEEASFESEQANKDHNEKHSQMREFGAPQFSNSENVAKDLPVDSLEGEDFEKEFSFLNNLLSSGSSSTSEFTQECQTAFGSPSASLTSQEPSMGSEPLAHSSRFLPSQLFDLGFHVAGAFNNWVSQEESELCLSHTDNQPVPSQSPKKLTRSPNNGNQDMSAWFNLFADLDPLSNPDAIGHSDDELLNA
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Molecular Weight
80.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ICA1L, or Intraflagellar Transport Protein 88 (IFT88)-like protein, has garnered increasing attention in the field of molecular biology due to its potential role in ciliary structure and function. Cilia are essential organelles involved in a variety of cellular processes, including signaling pathways and cellular motility, making understanding the proteins associated with them particularly crucial. ICA1L is implicated in the intraflagellar transport (IFT) mechanism, which is vital for the assembly and maintenance of cilia. Mutations or dysfunction in genes involved in this pathway can lead to a variety of ciliopathies, which are disorders characterized by abnormalities in cilia, affecting multiple organ systems. Given the significance of ICA1L in maintaining ciliary integrity, research has focused on the characterization, structural analysis, and functional studies of this recombinant protein. By exploring its functional domains, interactions with other ciliary proteins, and potential regulatory mechanisms, scientists aim to elucidate ICA1L's role in cilia-related diseases. Additionally, understanding ICA1L's structure may provide insights into the development of therapeutic strategies to target ciliopathies. Thus, the study of ICA1L and its recombinant protein forms not only contributes to basic biological knowledge but also holds promise for clinical advances in managing conditions linked to ciliary dysfunction.
