Analytical Data
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Gene name
HK2
- Application
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Alternative Names
KIF2A;KIF2;KNS2;Kinesin-like Protein KIF2A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52789
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Expression Region
1-917aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMIASHLLAYFFTELNHDQVQKVDQYLYHMR LSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHI AECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIV GTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQE IDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN TGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVST RSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKT VRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA LDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQ CIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEG EDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGT GSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVD ELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRA AQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVK DLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR
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Molecular Weight
105 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HK2, or hexokinase 2, is an enzyme that plays a crucial role in glycolysis, facilitating the conversion of glucose to glucose-6-phosphate, which is the first step in cellular energy production. Understanding the structure and function of HK2 is particularly significant due to its involvement in various metabolic processes and its implications in cancer biology. HK2 is often overexpressed in tumor cells, leading to increased glycolytic activity, a phenomenon known as the Warburg effect, where cancer cells preferentially utilize glycolysis for energy production even in the presence of oxygen. This metabolic reprogramming supports rapid cell proliferation and survival in the tumor microenvironment. Moreover, HK2 has been associated with tumor progression and resistance to therapy, making it a potential target for cancer treatment strategies. Recent studies have focused on the detailed biochemical properties of HK2, including its regulation, interaction with other metabolic pathways, and its potential as a biomarker for cancer diagnosis and prognosis. Research has also explored the development of HK2 inhibitors as therapeutic agents, aiming to disrupt its functions in cancer metabolism. Overall, the comprehensive study of HK2 holds promise for advancing our understanding of metabolic dysregulation in cancer and developing novel therapeutic approaches to improve patient outcomes.
