Analytical Data
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基因名
HES2
- Application
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别名
HES2;BHLHB40;Transcription factor HES-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y543
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表达区间
1-173aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HES2 (Hairy and Enhancer of Split 2) is a member of the Hes family of basic Helix-Loop-Helix (bHLH) transcription factors, which play critical roles in various biological processes, including neurogenesis, cell differentiation, and embryonic development. Research into HES2 has gained prominence due to its involvement in the Notch signaling pathway, a key regulator of cell communication and fate determination during development. Aberrant HES2 function has been linked to several pathologies, particularly in cancer and developmental disorders, highlighting its potential as a therapeutic target. The generation of recombinant HES2 protein facilitates detailed studies into its structure, function, and interactions with other molecular partners, providing insights into its regulatory mechanisms. Additionally, understanding the precise roles of HES2 in various cellular contexts could pave the way for novel strategies in regenerative medicine and cancer therapy, as it may help in manipulating cell fate decisions and improving tissue engineering approaches. Furthermore, the investigation of HES2 protein dynamics and its expression patterns could enhance our comprehension of its contribution to normal and pathological processes, making it a significant focus of contemporary biomedical research.
