Analytical Data
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Gene name
HES2
- Application
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Alternative Names
HES2;BHLHB40;Transcription factor HES-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y543
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Expression Region
1-173aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HES2 (Hairy and Enhancer of Split 2) is a member of the Hes family of basic Helix-Loop-Helix (bHLH) transcription factors, which play critical roles in various biological processes, including neurogenesis, cell differentiation, and embryonic development. Research into HES2 has gained prominence due to its involvement in the Notch signaling pathway, a key regulator of cell communication and fate determination during development. Aberrant HES2 function has been linked to several pathologies, particularly in cancer and developmental disorders, highlighting its potential as a therapeutic target. The generation of recombinant HES2 protein facilitates detailed studies into its structure, function, and interactions with other molecular partners, providing insights into its regulatory mechanisms. Additionally, understanding the precise roles of HES2 in various cellular contexts could pave the way for novel strategies in regenerative medicine and cancer therapy, as it may help in manipulating cell fate decisions and improving tissue engineering approaches. Furthermore, the investigation of HES2 protein dynamics and its expression patterns could enhance our comprehension of its contribution to normal and pathological processes, making it a significant focus of contemporary biomedical research.
