Analytical Data
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基因名
CD11a
- Application
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别名
CD11a；CDC2L2；CDC2L3；PITSLREB；Cyclin-dependent kinase 11A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20701
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表达区间
150-336aa
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氨基酸序列
CIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEG
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分子量
50.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD11a is a crucial component of the integrin family, specifically part of the leukocyte integrin LFA-1 (lymphocyte function-associated antigen-1), which plays a vital role in immune responses by facilitating the adhesion and migration of leukocytes to sites of inflammation. Research into CD11a recombinant proteins has gained significant attention due to their potential therapeutic applications in autoimmune diseases, cancer, and organ transplantation. Abnormalities in CD11a function can lead to impaired immune responses or contribute to inflammatory diseases, making it a valuable target for drug development. The generation of recombinant CD11a proteins allows for detailed studies of its structure-function relationships, providing insights into how it interacts with its ligands, such as ICAM-1 (intercellular adhesion molecule-1). This understanding can pave the way for novel therapeutic strategies aimed at modulating immune responses. Furthermore, engineering CD11a for enhanced binding characteristics or altered immunogenic profiles opens possibilities for its application in immunotherapy and vaccine development. The ongoing research into CD11a recombinant proteins not only elucidates its fundamental role in the immune system but also highlights its potential as a biomarker for disease progression and a target for innovative treatments.
