Analytical Data
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Gene name
HSH2D
- Application
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Alternative Names
Adaptor in lymphocytes of unknown function X; ALX ; FLJ14886; hematopoietic SH2 domain containing; Hematopoietic SH2 domain containing protein; Hematopoietic SH2 domain-containing protein; Hematopoietic SH2 protein; HSH2 ; Hsh2d; HSH2D_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96JZ2
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Expression Region
1-352aa
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AA Sequence
MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNRITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRSTVISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCIEVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
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Molecular Weight
64.46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSH2D, or Heterogeneous Nuclear Ribonucleoprotein H2D, is a reprogrammed protein that plays a critical role in various cellular processes, including RNA processing and gene regulation. The study of HSH2D has gained attention due to its involvement in essential biological functions and its potential implications in disease mechanisms, particularly in cancer and neurodegenerative disorders. As a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, HSH2D is known for its ability to bind pre-mRNA and influence splicing, stability, and transport of RNA molecules. Advances in molecular biology and genetic engineering techniques have enabled researchers to investigate the structural and functional characteristics of HSH2D, aiming to uncover its specific roles in cellular metabolism and its interactions with other regulatory proteins. Understanding the intricate workings of HSH2D can provide insights into how dysregulation of RNA synthesis and processing contributes to disease. Furthermore, the exploration of HSH2D as a potential biomarker or therapeutic target is a promising avenue, as it could lead to novel strategies for diagnosis and treatment. This growing interest underscores the importance of HSH2D in cellular biology and its relevance in biomedical research, supporting further investigation into its mechanisms and applications in health and disease.
