Analytical Data
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Gene name
GTF2E2
- Application
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Alternative Names
GTF2E2;TF2E2;Transcription initiation factor IIE subunit beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29084
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Expression Region
1-291aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMDPSLL RERELFKKRA LSTPVVEKRS ASSESSSSSS KKKKTKVEHG GSSGSKQNSD HSNGSFNLKA LSGSSGYKFG VLAKIVNYMK TRHQRGDTHP LTLDEILDET QHLDIGLKQK QWLMTEALVN NPKIEVIDGK YAFKPKYNVR DKKALLRLLD QHDQRGLGGI LLEDIEEALP NSQKAVKALG DQILFVNRPD KKKILFFNDK SCQFSVDEEF QKLWRSVTVD SMDEEKIEEY LKRQGISSMQ ESGPKKVAPI QRRKKPASQK KRRFKTHNEH LAGVLKDYSD ITSSK
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GTF2E2, or General Transcription Factor II E2, is a crucial protein involved in the transcription initiation process in eukaryotic cells. It plays a significant role in the assembly and stabilization of the transcription machinery, facilitating the accurate expression of various genes. Research on GTF2E2 has gained momentum due to its involvement in essential biological processes and its potential links to various diseases. Abnormalities in GTF2E2 expression or function have been implicated in transcriptional dysregulation, which can lead to pathologies including cancer and developmental disorders. The recombinant expression of GTF2E2 allows for an in-depth study of its structural and functional properties, as well as its interactions with other transcription factors and co-factors. This protein can be studied in vitro to elucidate its specific roles within the transcriptional regulatory networks and its effects on gene expression patterns. Moreover, understanding GTF2E2's mechanisms could provide insights into novel therapeutic approaches for diseases linked to transcriptional misregulation, making it a significant target for biomedical research. Thus, the exploration of recombinant GTF2E2 not only enhances our understanding of fundamental biological processes but also opens up new avenues for the development of targeted therapies in transcription-related disorders.
