Analytical Data
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基因名
LIN28A
- Application
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别名
LIN28A；CSDD1；LIN28；ZCCHC1；Protein lin-28 homolog A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H9Z2
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表达区间
2-209aa
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氨基酸序列
GSVSNQQFAG GCAKAAEEAP EEAPEDAARA ADEPQLLHGA GICKWFNVRM GFGFLSMTAR AGVALDPPVD VFVHQSKLHM EGFRSLKEGE AVEFTFKKSA KGLESIRVTG PGGVFCIGSE RRPKGKSMQK RRSKGDRCYN CGGLDHHAKE CKLPPQPKKC HFCQSISHMV ASCPLKAQQG PSAQGKPTYF REEEEEIHSP TLLPEAQN
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LIN28A is a highly conserved RNA-binding protein that plays a pivotal role in regulating the developmental timing of gene expression, particularly in stem cells and embryos. Originally identified in the context of let-7 microRNA regulation, LIN28A modulates various biological processes such as cellular reprogramming, differentiation, and metabolism. Its aberrant expression has been linked to numerous cancers, highlighting its potential as a therapeutic target. By studying LIN28A recombinant proteins, researchers aim to elucidate its functional mechanisms, including the interactions with specific RNA molecules and other cellular proteins. This research not only enhances our understanding of LIN28A’s role in normal cellular processes but also sheds light on its involvement in tumorigenesis and stem cell biology. Furthermore, the development of LIN28A-based therapeutic strategies could pave the way for innovative treatments for various diseases, including cancer. Overall, the investigation of LIN28A recombinant proteins serves as a foundation for advancing molecular biology and offering new insights into developmental and pathological processes.
