Analytical Data
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Gene name
MIOX
- Application
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Alternative Names
MIOX；ALDRL6；KSP32；RSOR；Inositol oxygenase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UGB7
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Expression Region
1-285aa
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AA Sequence
MKVTVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW
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Molecular Weight
33 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MIOX, or myo-inositol oxygenase, is a pivotal enzyme that catalyzes the oxidation of myo-inositol to myo-inositol 1-phosphate, playing a significant role in inositol metabolism. Research into MIOX has gained momentum due to its implications in various physiological processes and disease states, including diabetes, cancer, and neurodegenerative disorders. In particular, alterations in inositol signaling pathways can affect insulin signaling and glucose metabolism, linking MIOX activity to metabolic health. Furthermore, recent studies suggest that MIOX may influence cellular redox status and inflammation, making it a potential therapeutic target. The enzyme's unique mechanism of action and its role in producing reactive oxygen species underscore the importance of understanding its biological functions. Investigating the structure-function relationships of MIOX and its interactions with other biomolecules may provide insights into its regulatory mechanisms and potential therapeutic applications. As a result, ongoing research aims to delineate the molecular pathways involving MIOX, identify its regulatory networks, and explore its potential as a biomarker or therapeutic target in various diseases. This growing body of work underscores MIOX's critical role in cellular physiology and the relevance of exploring its molecular function within the broader context of metabolism and disease.
