Analytical Data
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基因名
Flt3L
- Application
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别名
Flt3L;Fms-related tyrosine kinase 3 ligand
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49771
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表达区间
27-184aa
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氨基酸序列
TQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGALWRL VLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTN ISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEA TAPTAPQP
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Flt3L, or Fms-like tyrosine kinase 3 ligand, is a pivotal hematopoietic growth factor that plays a crucial role in the proliferation, differentiation, and survival of hematopoietic progenitor cells and dendritic cells. It is primarily involved in the regulation of immune responses and has garnered significant interest in cancer immunotherapy due to its ability to enhance the function of dendritic cells, which are vital for initiating T-cell-mediated immune responses. The recombinant form of Flt3L (recombinant Flt3L) has been developed for therapeutic applications, particularly in boosting the immune system's response against tumors. Studies have shown that administering recombinant Flt3L can promote the expansion of dendritic cells and other immune cell types, thereby potentially improving the efficacy of various cancer treatments. Additionally, Flt3L has been explored for its ability to enhance the engraftment of hematopoietic stem cells in transplantation settings, making it relevant in both cancer and regenerative medicine research. Given its critical role in immune system modulation, recombinant Flt3L is being investigated not only for its standalone effects but also in combination with other immunotherapeutic agents to overcome immune checkpoints and improve patient outcomes in oncological treatments. Overall, the research surrounding Flt3L and its recombinant protein form is a rapidly evolving field, with promising implications for enhancing immune responses in cancer therapy and cellular therapies.












