Analytical Data
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基因名
GRSF1
- Application
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别名
G rich RNA sequence binding factor 1; G rich sequence binding factor 1; G-rich sequence factor 1; GRSF-1; GRSF1; GRSF1_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12849
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表达区间
1-459aa
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氨基酸序列
MAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSAAAAASQTRGLQTGPVPPGRLAGPPAVATSAAAAAAASYPALRASLLPQSLAAAAAVPTRSYSQESKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFETHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK
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分子量
77.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRSF1 (G-rich sequence binding factor 1) is a member of the RNA-binding protein family that has garnered attention for its role in post-transcriptional regulation of gene expression. Emerging studies indicate that GRSF1 is involved in various biological processes, including cellular stress response, apoptosis, and regulation of translation, particularly in the context of cancer and neurodegenerative diseases. The protein possesses RNA recognition motifs that allow it to bind to specific RNA sequences, suggesting its potential involvement in modulating mRNA stability and translation efficiency. The significance of GRSF1 is further underscored by its differential expression in various tissues and its association with critical pathways that could influence tumorigenesis and neuronal function. Despite these insights, detailed mechanistic understanding of GRSF1's actions at the molecular level remains limited, driving the need for comprehensive studies including the characterization of recombinant GRSF1 proteins. The recombinant production of GRSF1 provides a valuable tool to explore its biochemical properties, interaction partners, and functional roles in cellular contexts. Through structural and functional analyses of the recombinant protein, researchers aim to elucidate the precise mechanisms by which GRSF1 exerts its regulatory effects, thereby paving the way for potential therapeutic applications in diseases where GRSF1 is implicated.
