Analytical Data
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Gene name
GPR85
- Application
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Alternative Names
GPR85; SREB2; Probable G-protein coupled receptor 85; Super conserved receptor expressed in brain 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60893
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Expression Region
1-370aa
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AA Sequence
MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCAFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI
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Molecular Weight
68.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GPR85, a member of the G protein-coupled receptor (GPCR) family, has garnered significant attention in recent years due to its potential role in various physiological and pathological processes. Initially identified as a receptor expressed in the central nervous system, GPR85 has been implicated in neurodevelopment, immune responses, and metabolic regulation. Abnormal expression and function of GPR85 have been linked to several neuropsychiatric disorders, including anxiety and schizophrenia, highlighting its relevance in mental health. The receptor’s ligand, which remains to be fully characterized, and its signaling pathways offer a promising avenue for therapeutic interventions. Recombinant GPR85 protein research aims to elucidate its molecular mechanisms, interactions, and the role it plays in these conditions, providing insights essential for drug discovery and the development of targeted therapies. Additionally, understanding GPR85’s structure and function can facilitate the rational design of agonists or antagonists, paving the way for novel treatments that may improve patient outcomes in diseases associated with dysregulated GPCR signaling.
