Analytical Data
-
基因名
KCC4
- Application
-
别名
KCC4；CAMK；CAMK-GR；CAMKIV；Calcium/calmodulin-dependent Protein kinase type IV
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q16566
-
表达区间
1-473aa
-
氨基酸序列
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
-
分子量
51.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The KCC4 (K+ Cl- cotransporter 4) protein is part of the SLC12 family of transporters, playing a crucial role in regulating cellular ion homeostasis and volume. It is primarily expressed in various tissues, including the kidney, brain, and heart, where it contributes to the reabsorption of potassium and chloride ions, essential for maintaining electrolyte balance. Dysregulation of KCC4 has been implicated in several physiological and pathological conditions, such as hypertension, cystic fibrosis, and neurological disorders. Recent research has focused on the structural and functional characterization of KCC4, utilizing techniques such as cryo-electron microscopy and X-ray crystallography to elucidate its transport mechanism and substrate specificity. Understanding the molecular basis of KCC4 activity could provide insights into its role in disease processes and offer potential therapeutic targets. Furthermore, the investigation of KCC4 as a recombinant protein has opened avenues for the development of innovative drug delivery systems and biosensors, enhancing our ability to monitor and manipulate ion transport in various biological settings. Overall, the study of KCC4 is pivotal in advancing our knowledge of cellular transport mechanisms and their implications for human health.
