Analytical Data
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Gene name
HDT2
- Application
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Alternative Names
HDT2;HD2;HD2B;HDA4;Histone deacetylase HDT2
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q56WH4
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Expression Region
1-306aa
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AA Sequence
MEFWGVAVTPKNATKVTPEEDSLVHISQASLDCTVKSGESVVLSVTVGGA KLVIGTLSQDKFPQISFDLVFDKEFELSHSGTKANVHFIGYKSPNIEQDD FTSSDDEDVPEAVPAPAPTAVTANGNAGAAVVKADTKPKAKPAEVKPAEE KPESDEEDESDDEDESEEDDDSEKGMDVDEDDSDDDEEEDSEDEEEEETP KKPEPINKKRPNESVSKTPVSGKKAKPAAAPASTPQKTEEKKKGGHTATP HPAKKGGKSPVNANQSPKSGGQSSGGNNNKKPFNSGKQFGGSNNKGSNKG KGKGRA
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HDT2, a member of the histone deacetylase (HDAC) family, has garnered significant attention due to its role in regulating gene expression and its implications in various diseases, particularly cancer. Histone deacetylases are crucial for maintaining epigenetic control of chromatin structure, influencing transcriptional activity and cellular processes such as differentiation, proliferation, and apoptosis. The deregulation of HDACs, including HDT2, has been associated with tumorigenesis and other pathological conditions. Consequently, HDT2 serves as a potential therapeutic target, with studies focusing on its structural characterization and functional analysis to develop specific inhibitors. By comprehending the mechanisms through which HDT2 modulates genetic regulation, researchers aim to elucidate its contribution to disease progression and explore its utilization in innovative treatment strategies. The recombinant protein production of HDT2 enables comprehensive biochemical and biophysical studies, paving the way for new insights into its enzymatic activities and inhibition. Enhanced understanding of HDT2's function in cellular pathways may reveal novel diagnostic and therapeutic avenues for HDAC-inhibitor-based cancer therapies and other diseases linked to epigenetic dysregulation.











