Analytical Data
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Gene name
ELP4
- Application
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Alternative Names
ELP4；C11orf19；PAXNEB;Elongator complex Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96EB1
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Expression Region
1-424aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMAAVATCGSVAASTGSAVATASKSNVT SFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGG LAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSS SRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKL LQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGN SHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGL ESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKL FTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELP4, or elongator protein 4, is a crucial component of the elongator complex involved in the regulation of transcription and mRNA processing. This protein plays a significant role in various cellular processes, including gene expression, chromatin remodeling, and RNA modification. Research into ELP4 has gained momentum due to its association with certain diseases, such as neurodegenerative disorders and cancer. Mutations or dysregulation of ELP4 are linked to impaired neuronal function and cell proliferation. Moreover, ELP4 has been implicated in the modification of transfer RNAs, which are essential for protein synthesis, thereby affecting translational fidelity and efficiency. Understanding the structure and function of ELP4, as well as its interactions with other molecular partners, provides valuable insights into its biological role and potential therapeutic targets. Recent advancements in recombinant protein technology have facilitated the study of ELP4, enabling researchers to express and purify this protein for detailed biochemical and functional analyses. The exploration of ELP4's activity, regulation, and involvement in various signaling pathways could lead to novel strategies for drug development and intervention in diseases associated with its dysfunction. Overall, ELP4 is an important molecule in the field of molecular biology, and ongoing research aims to clarify its diverse roles within the cell, contributing to the broader understanding of cellular homeostasis and pathogenesis.
