Analytical Data
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基因名
DTNBP1
- Application
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别名
DTNBP1；BLOC1S8;Dysbindin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96EV8
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表达区间
1-351aa
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氨基酸序列
MLETLRERLL SVQQDFTSGL KTLSDKSREA KVKSKPRTVP FLPKYSAGLE LLSRYEDTWA ALHRRAKDCA SAGELVDSEV VMLSAHWEKK KTSLVELQEQ LQQLPALIAD LESMTANLTH LEASFEEVEN NLLHLEDLCG QCELERCKHM QSQQLENYKK NKRKELETFK AELDAEHAQK VLEMEHTQQM KLKERQKFFE EAFQQDMEQY LSTGYLQIAE RREPIGSMSS MEVNVDMLEQ MDLMDISDQE ALDVFLNSGG EENTVLSPAL GPESSTCQNE ITLQVPNPSE LRAKPPSSSS TCTDSATRDI SEGGESPVVQ SDEEEVQVDT ALATSHTDRE ATPDGGEDSD S
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DTNBP1, or dystrobrevin-binding protein 1, is a protein that plays a crucial role in synaptic function and neurotransmitter release. It has garnered significant interest in the field of neuroscience due to its association with several neuropsychiatric disorders, including schizophrenia and bipolar disorder. Research has shown that mutations and alterations in the expression of DTNBP1 are linked to these conditions, making it a potential biomarker and therapeutic target. The protein is also involved in the regulation of the cytoskeleton and synaptic vesicle dynamics, processes essential for effective neuronal communication. Given its diverse physiological roles, the study of recombinant DTNBP1 has become vital for understanding its molecular mechanisms and interactions within the synaptic environment. This research could provide insights into the pathophysiology of mental disorders and may lead to the development of novel treatment strategies aimed at restoring synaptic function in affected individuals. Moreover, the production and characterization of recombinant DTNBP1 allow researchers to explore its structural properties and functional dynamics in vitro, advancing our knowledge of synaptic biology and its implications for human health.
