Analytical Data
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基因名
KAT5
- Application
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别名
KAT5；HTATIP；TIP60；Histone acetyltransferase KAT5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92993
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表达区间
3-513aa
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氨基酸序列
EVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
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分子量
62.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The KAT5 (Lysine Acetyltransferase 5), also known as TIP60, is a crucial enzyme in the regulation of chromatin dynamics and gene expression through its role in histone acetylation. It is involved in various cellular processes, including DNA repair, cell cycle progression, and apoptosis, highlighting its importance in maintaining genomic stability. Dysregulation of KAT5 has been implicated in several cancers and neurodegenerative diseases, making it a focal point of research in cancer biology and therapeutic development. Recent studies have revealed that KAT5 interacts with multiple protein partners and is involved in complex signaling pathways, underscoring its versatility and impact on cellular function. Researchers are particularly interested in understanding how the modulation of KAT5 activity can influence tumor progression and response to chemotherapy. The development of specific inhibitors or activators of KAT5 represents a promising avenue in targeted cancer therapies. This background forms the foundation for ongoing investigations into the structural and functional characteristics of KAT5 recombinant proteins, aiming to elucidate their mechanisms of action and potential applications in disease treatment.
