Analytical Data
-
Gene name
CTDSP1
- Application
-
Alternative Names
CTDSP1；POLR2;DNA-directed RNA polymerase II subunit RPB1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9GZU7
-
Expression Region
1-260aa
-
AA Sequence
MDSSAVITQI SKEEARGPLR GKGDQKSAAS KPRSRGILH SLFCCVCRDD GEALPAHSGA PLLVEENGAI PKTPVQYLLP EAKAQDSDKI VVIDLDETL VHSSFKPVNN ADFIIPVEID GVVHQVYVLK RPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGA FRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPAS VFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDVY SVLRQPRPGS
-
Molecular Weight
56 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CTDSP1, or CTD small phosphatase 1, is a member of the phosphatase family that plays a crucial role in the regulation of RNA polymerase II transcription through the dephosphorylation of the C-terminal domain (CTD) of the RNA polymerase II large subunit. This process is essential for the proper progression of transcription and the processing of RNA, impacting gene expression and cellular responses. Given its involvement in transcriptional regulation, CTDSP1 has garnered attention in the context of various diseases, particularly cancer, where aberrant transcriptional controls contribute to tumorigenesis. RecENT studies have highlighted its potential as a therapeutic target, revealing that modulation of CTDSP1 activity can influence the expression of oncogenes and tumor suppressor genes. Furthermore, the study of CTDSP1 and its interactions with other proteins offers insights into the complex networks governing transcriptional regulation. Understanding CTDSP1 at the molecular level, including the characterization of its recombinant protein, is pivotal for developing targeted therapies that could restore normal transcriptional regulation in pathological conditions. Thus, ongoing research aims to elucidate the functional dynamics and structural properties of CTDSP1, providing a foundation for potential clinical applications in cancer therapeutics and beyond.
