Analytical Data
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基因名
SLC30A10
- Application
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别名
SLC30A10；ZNT10；ZNT8；Calcium/manganese antiporter SLC30A10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6XR72
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表达区间
300-485aa
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氨基酸序列
KETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
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分子量
27.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC30A10, a member of the SLC (solute carrier) family, is primarily known for its role in the transport of manganese and other metals across cellular membranes. Research has revealed that mutations in the SLC30A10 gene are associated with disorders such as manganese transport disease, characterized by manganese accumulation that leads to neurological dysfunction. Given its critical physiological role, the study of recombinant SLC30A10 protein has gained prominence in recent years. By producing this protein in a laboratory setting, researchers are able to investigate its structure, function, and interaction with other cellular components. Furthermore, understanding the mechanisms of metal ion transport and the impact of pathological mutations on its function can provide insights into potential therapeutic strategies for related diseases. The recombinant protein can be utilized in various assays to elucidate transport kinetics, substrate specificity, and the effects of different metal ions on its activity. This research not only enhances our comprehension of manganese homeostasis but also contributes to the broader field of metal ion transport in human health and disease.
