Analytical Data
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基因名
MTMR7
- Application
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别名
MTMR7；Myotubularin-related Protein 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y216
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表达区间
1-660aa
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氨基酸序列
MEHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDPRKETWILHSQISTIEKQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
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分子量
91.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTMR7 (Membrane Transport Methylation Regulator 7) is a member of the myotubularin family of lipid phosphatases, which play crucial roles in regulating cellular processes such as endosomal trafficking, autophagy, and membrane dynamics. Research into MTMR7 has gained significant attention due to its implications in various cellular functions and potential links to diseases, particularly those related to muscle disorders and neurodegeneration. Mutations in the MTMR7 gene have been associated with conditions like Charcot-Marie-Tooth disease, which underscores the protein's importance in proper neuronal function and maintenance. As a phosphoinositide phosphatase, MTMR7 is involved in the regulation of phosphatidylinositol 3-phosphate (PI3P) levels, which are vital for cellular signaling pathways. Understanding the structural and functional mechanisms of MTMR7 has the potential to unveil new therapeutic targets for related diseases. Additionally, the study of MTMR7 can provide insights into the broader context of myotubularin family members, facilitating advancements in biotechnology and drug development focused on modulating lipid signaling pathways. Overall, ongoing research aims to characterize MTMR7's biochemical properties, elucidate its roles in cellular pathways, and explore its potential as a biomarker or therapeutic target in related pathologies.
