Analytical Data
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Gene name
SLC16A8
- Application
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Alternative Names
SLC16A8；MCT3；Monocarboxylate transporter 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95907
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Expression Region
1-504aa
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AA Sequence
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
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Molecular Weight
52.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC16A8, a member of the solute carrier family, encodes a sodium-dependent monocarboxylate transporter primarily involved in the transport of lactate, pyruvate, and other monocarboxylates across cell membranes. Its role is critical in various physiological processes, including energy metabolism, pH regulation, and intercellular signaling. Dysregulation of SLC16A8 has been implicated in metabolic disorders, cancer progression, and neurological diseases, prompting researchers to investigate its structure and function more closely. Recombination techniques allow for the expression of SLC16A8 in various systems, facilitating the study of its biochemical properties and transport mechanisms. The generated recombinant proteins can be used to elucidate the transport kinetics, substrate specificity, and regulatory mechanisms of SLC16A8, providing insights into its biological significance and potential as a therapeutic target. Understanding the structure-function relationship of SLC16A8 through recombinant protein studies may lead to novel interventions for diseases associated with its dysfunction and enhance our comprehension of cellular metabolism in health and disease.
