Analytical Data
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Gene name
FZR1
- Application
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Alternative Names
FZR1；CDH1；FYR；FZR；Fizzy-related Protein homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UM11
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Expression Region
1-493aa
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AA Sequence
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR
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Molecular Weight
70.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The FZR1 protein, also known as Fizzy/Cell Division Cycle 20 Homolog 1, plays a crucial role in the regulation of the cell cycle and the process of cell division. It acts as an essential activator of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that targets specific proteins for degradation, thereby ensuring the proper progression of mitosis. Abnormalities in FZR1 function have been linked to various human diseases, including cancer, where dysregulation of the cell cycle can lead to uncontrolled cell proliferation. The study of recombinant FZR1 protein has garnered attention as researchers aim to elucidate its structure-function relationship, regulatory mechanisms, and interactions with other cell cycle proteins. By expressing FZR1 in vitro, scientists can analyze its biochemical properties, determine how it influences APC/C activity, and explore its potential as a therapeutic target. Understanding FZR1's role in cell cycle regulation not only enhances our knowledge of fundamental cellular processes but also opens avenues for innovative cancer treatment strategies. Furthermore, this research is pivotal in dissecting the molecular pathways involved in cell division, which can lead to the development of novel biomolecular tools and therapeutic agents.
