Analytical Data
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Gene name
LPCAT2
- Application
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Alternative Names
LPCAT2；AGPAT11；AYTL1；Lysophosphatidylcholine acyltransferase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7L5N7
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Expression Region
1-544aa
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AA Sequence
MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSDKKDD
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Molecular Weight
60.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LPCAT2 (Lysophosphatidylcholine acyltransferase 2) is a crucial enzyme involved in lipid metabolism, specifically in the biosynthesis of phosphatidylcholine, a key component of cell membranes. Recent studies have illuminated the role of LPCAT2 in various physiological and pathological processes, including inflammation, cancer, and metabolic disorders. Given its significance in maintaining cellular lipid homeostasis, LPCAT2 has attracted interest as a potential therapeutic target for diseases like non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Research on the recombinant expression of LPCAT2 enables scientists to obtain the protein in purified form for biochemical and structural studies, facilitating a deeper understanding of its enzymatic mechanism and regulatory functions. Advances in protein engineering and expression systems have made it feasible to produce LPCAT2 in sufficient quantities for functional assays and high-resolution structural analysis. This knowledge may lead to the identification of specific inhibitors or modulators of LPCAT2 activity, with the potential for new drug development strategies. Furthermore, studying the interactions of LPCAT2 with other lipid metabolic pathways could provide insights into its broader role in cell signaling and disease progression, underscoring the importance of LPCAT2 in health and disease. Overall, the research on LPCAT2 recombinant protein is vital for elucidating the enzyme's biological functions and its implications in translational medicine.
