Analytical Data
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基因名
ALDOS
- Application
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别名
ALDOS；Cytochrome P450 11B2. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19099
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表达区间
25-503aa
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氨基酸序列
GTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
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分子量
71.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ALDOS (Aldose Reductase-Like Protein) is a member of the aldo-keto reductase superfamily, which is involved in various metabolic processes, including glucose metabolism and oxidative stress response. The study of ALDOS has gained significance due to its potential implications in numerous diseases, such as diabetes, diabetic complications, and neurodegenerative disorders. Research has shown that ALDOS plays a crucial role in the conversion of aldoses to their corresponding sugar alcohols, particularly in the context of hyperglycemia, where excessive glucose leads to its reduced forms, contributing to cellular damage and oxidative stress. Understanding the molecular mechanisms underlying ALDOS function and its regulation could open avenues for therapeutic interventions aimed at mitigating the adverse effects of metabolic disorders. Additionally, the recombinant expression of ALDOS provides an opportunity to investigate its enzyme kinetics, structural properties, and interaction with various substrates. By elucidating the functional aspects of ALDOS through recombinant protein studies, researchers aim to develop targeted treatments that can effectively modulate its activity and reduce the pathological consequences associated with its dysregulation. Consequently, the exploration of ALDOS as a potential drug target is at the forefront of current biomedical research, with the objective of improving patient outcomes in metabolic diseases.
