Cat: PA1000-9374

Recombinant Human CCR3 Protein,His

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Analytical Data

  • 基因名

    CCR3

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CCR3;CMKBR3;C-C chemokine receptor type 3

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P51677

  • 表达区间

    1-355aa

  • 氨基酸序列

    MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF

  • 分子量

    69.3 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CCR3, or C-C chemokine receptor type 3, is a member of the chemokine receptor family, primarily involved in the immune response and inflammation. It plays a crucial role in the migration of eosinophils, basophils, and T-helper type 2 (Th2) cells to sites of allergic inflammation and parasitic infections. The significance of CCR3 in various pathological conditions, such as asthma, allergic rhinitis, and autoimmune diseases, has prompted extensive research into its structure, function, and signaling mechanisms. Understanding the molecular interactions and pathways associated with CCR3 is essential for developing targeted therapies aimed at modulating its activity. Recombining CCR3 protein presents opportunities for studying its biological functions in vitro and in vivo, paving the way for potential therapeutic applications. By investigating CCR3’s surface interactions and ligand binding, researchers aim to identify small molecules or antibodies that can specifically inhibit its activity, offering new strategies for treating related diseases. Furthermore, CCR3 has emerged as a potential therapeutic target due to its involvement in mediating inflammatory responses, thereby contributing to the development of novel anti-inflammatory drugs. Given the rising prevalence of allergic disorders and inflammatory conditions, the study of CCR3 and its recombinant protein continues to be a significant area of biomedical research, promising insights into the modulation of immune responses and therapeutic interventions.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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