Analytical Data
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基因名
CCR2
- Application
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别名
CCR2；CMKBR2；C-C chemokine receptor type 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41597
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表达区间
1-42aa
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氨基酸序列
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGA
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR2 (C-C chemokine receptor type 2) is a crucial receptor in the immune system, involved in the recruitment of monocytes and other immune cells to sites of inflammation, making it a key player in various pathological conditions, including cardiovascular diseases, autoimmune disorders, and cancer. Research on CCR2 has gained momentum due to its potential as a therapeutic target for inflammatory and fibrotic diseases. Recombinant CCR2 proteins are vital for studying the structure-function relationships of this receptor, understanding its signaling pathways, and discovering novel drug candidates that can modulate its activity. The use of recombinant techniques allows for the production of purified CCR2 proteins, enabling detailed investigations of their biochemical properties and interactions with ligands. Consequently, CCR2 recombinant proteins serve not only as essential tools for elucidating the roles of this receptor in disease but also as potential platforms for developing targeted therapies that could benefit patients suffering from a range of inflammatory conditions. The ongoing research into CCR2 and its recombinant variants positions this receptor as a promising target in the field of immunology and pharmacology, highlighting the importance of continued exploration into its molecular mechanisms and therapeutic implications.
