Analytical Data
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基因名
CPLX1
- Application
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别名
CPLX1;Complexin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14810
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表达区间
1-134aa
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氨基酸序列
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPLX1 (Complexin 1) is a key protein involved in the regulation of neurotransmitter release at synapses, playing a crucial role in synaptic transmission and plasticity. It functions by binding to the SNARE complex, mediating vesicle fusion and the release of neurotransmitters, and ensuring the proper synchronization of neuronal communication. Dysregulation of CPLX1 has been implicated in various neurological disorders, including autism spectrum disorders and schizophrenia, highlighting its importance in maintaining synaptic health and functionality. Recent studies have focused on the characterization and production of recombinant CPLX1 proteins to elucidate its structure-function relationships, interactions with other synaptic proteins, and the molecular mechanisms underlying its role in neurotransmission. By utilizing recombinant DNA technology, researchers aim to produce CPLX1 in sufficient quantities for detailed biophysical and biochemical analysis, enabling the exploration of its effects on synaptic activity and potential therapeutics for synaptic dysfunction. Understanding CPLX1's precise functions and interactions at the molecular level could provide valuable insights into synaptic biology and pathophysiology, paving the way for novel treatments for related neurological conditions.
