Analytical Data
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Gene name
STEAP2
- Application
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Alternative Names
STEAP2；PCANAP1；STAMP1；Metalloreductase STEAP2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFT2
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Expression Region
1-490aa
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AA Sequence
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STEAP2, or Six-Transmembrane Epithelial Antigen of the Prostate 2, is a member of the STEAP family of proteins, which are integral membrane proteins believed to play a role in various biological processes, including cellular adhesion, signaling, and metalloreduction. Originally identified as a prostate cancer antigen, STEAP2 has garnered attention due to its overexpression in certain tumors, making it a potential biomarker and therapeutic target for cancer diagnosis and treatment. Research indicates that STEAP2 is involved in the internalization of metal ions and contributes to regulating intracellular metal homeostasis. Its distinctive structure, featuring six transmembrane domains, allows for interactions with other membrane-associated proteins, which can influence cellular functions. Furthermore, STEAP2's expression patterns in various tissues, particularly in the prostate and many malignancies, have fueled investigations into its role in tumor progression and metastasis. Studies have increasingly focused on the development of recombinant STEAP2 proteins for use in immunological assays and as a platform for targeted cancer therapies, highlighting its potential in the field of cancer immunotherapy and precision medicine. Ongoing research aims to elucidate the precise mechanisms of STEAP2 function and its interactions within cellular pathways, paving the way for novel treatment strategies leveraging this protein in oncology.
