Analytical Data
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基因名
A2BP1
- Application
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别名
A2BP1；A2BP；A2BP1；FOX1；RNA binding Protein fox-1 homolog 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWB1
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表达区间
1-397aa
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氨基酸序列
MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP EYTGQTTVPE HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG QPQTQPSENT ENKSQPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF NERGSKGFGF VTFENSADAD RAREKLHGTV VEGRKIEVNN ATARVMTNKK TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM YSAPSSLVYT SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPY
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
A2BP1 (Ataxia-Telangiectasia Mutated Protein 1) is a RNA-binding protein primarily known for its significant role in the regulation of alternative splicing and gene expression during neuronal development. Research has shown that A2BP1 is crucial for the proper differentiation of neurons and the establishment of synaptic connections, implicating its involvement in neurodevelopmental disorders. Mutations or dysregulation of A2BP1 have been linked to various conditions, including autism spectrum disorders and intellectual disabilities. The study of A2BP1-derived recombinant proteins has gained traction as a means to elucidate its functional mechanisms at the molecular level and to explore its potential as a therapeutic target. These recombinant proteins allow researchers to investigate the protein's interactions with RNA and other cellular components, offering insights into its role in modulating splicing and transcriptional regulation. Advances in techniques such as CRISPR/Cas9 and high-throughput sequencing have further propelled the understanding of A2BP1’s functions, enhancing the ability to design experiments that can dissect the complexities of its involvement in neurodevelopment. Overall, the study of A2BP1 and its recombinant proteins stands as a promising frontier in neuroscience, with implications for understanding the underpinnings of neurodevelopmental disorders and devising innovative therapeutic strategies.
