Analytical Data
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Gene name
ATXN10
- Application
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Alternative Names
ATXN10；SCA10；Ataxin-10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UBB4
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Expression Region
1-475aa
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AA Sequence
MAAPRPPPAR LSGVMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSSHA VELACRDPSQ VENLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLILLFRE LRVEQESLLT AFRCGLQFLG NIASRNEDSQ SIVWVHAFPE LFLSCLNHPD KKIVAYSSMI LFTSLNHERM KELEENLNIA IDVIDAYQKH PESEWPFLII TDLFLKSPEL VQAMFPKLNN QERVTLLDLM IAKITSDEPL TKDDIPVFLR HAELIASTFV DQCKTVLKLA SEEPPDDEEA LATIRLLDVL CEMTVNTELL GYLQVFPGLL ERVIDLLRVI HVAGKETTNI FSNCGCVRAE GDISNVANGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL ILDNCNISDS NPFLTQWVIY AIRNLTEDNS QNQDLIAKME EQGLADASLL KKVGFEVEKK GEKLILKSTR DTPKP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATXN10 (Ataxin-10) is a protein encoded by the ATXN10 gene, which is primarily implicated in spinocerebellar ataxia, a group of neurodegenerative disorders characterized by impaired coordination and balance. The interest in studying ATXN10 stems from its role in various cellular processes, including RNA metabolism, protein aggregation, and neurodegeneration. Mutations in the ATXN10 gene have been linked to spinocerebellar ataxia type 10 (SCA10), which is marked by progressive ataxia, peripheral neuropathy, and cognitive decline. The unique aspect of SCA10 is the presence of an expanded repeat sequence in the ATXN10 gene, leading to the production of toxic RNA species that disrupt normal cellular functions. Research focused on recombinant ATXN10 protein provides insights into its biochemical properties, interactions with other cellular components, and the underlying mechanisms of SCA10 pathology. By producing and characterizing recombinant ATXN10, scientists aim to elucidate its functional domains and signaling pathways involved in neurodegeneration. Furthermore, understanding the structural and functional aspects of ATXN10 can pave the way for developing potential therapeutic strategies to counteract the detrimental effects of its mutations, offering hope for targeted interventions in SCA10 and related disorders. The ongoing research into ATXN10 not only enhances our comprehension of its role in neurobiology but also contributes to the broader field of neurodegenerative disease research, ultimately seeking to identify novel biomarkers and therapeutic targets.
