Analytical Data
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基因名
Grb10
- Application
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别名
Grb10；GRBIR；KIAA0207；Growth factor receptor-bound Protein 10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13322-3
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表达区间
1-536aa
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氨基酸序列
MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQR VQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGS LPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNS WTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNP MNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWK KLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYR IPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEE GHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIK QQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLD DGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
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分子量
87 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Grb10 (Growth factor receptor-bound protein 10) is an adaptor protein that plays a significant role in various cellular processes, including growth, metabolism, and signal transduction. Research into Grb10 has gained momentum because of its involvement in insulin signaling pathways and its potential implications in metabolic disorders like obesity and type 2 diabetes. Furthermore, Grb10 has been shown to interact with various receptor tyrosine kinases, which are crucial for cell signaling in response to growth factors. The interest in Grb10 is also fueled by its unique regulatory functions, particularly in the context of imprinted genes and their effects on developmental biology. The study of Grb10 recombinant proteins is vital for elucidating its structural and functional characteristics, providing insights into its molecular mechanisms. By producing and analyzing recombinant Grb10, researchers aim to uncover its detailed role in cellular signaling and its potential as a therapeutic target. Moreover, understanding the dynamics of Grb10's interactions can open avenues for novel drug developments aimed at treating metabolic diseases and conditions related to aberrant signaling pathways. Overall, Grb10's intricate involvement in essential biological processes renders it a key focus in both basic and translational research, underscoring the necessity for further studies on its recombinant forms to fully exploit its potential in biomedical applications.
