Analytical Data
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基因名
CHI3L1
- Application
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别名
CHI3L1；Chitinase-3-like Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36222
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表达区间
22-383aa
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氨基酸序列
YKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEW NDVTLYGMLN TLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTF IKSVPPFLRTHGFDGLDLAWLY PGRRDKQHFTTLIKEMKAEFIKEAQP GKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFI SIMTYDFHGAWRGT TGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTF GR SFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILG QQVPYATK GNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQG SFCGQDLRFPLTNAIKDALA AT
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分子量
41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHI3L1, also known as chitinase 3-like 1 or YKL-40, is a human glycoprotein that belongs to the chitinase-like family of proteins, which are implicated in various biological processes, including inflammation, tissue remodeling, and cancer progression. Elevated levels of CHI3L1 have been associated with several diseases, such as asthma, arthritis, and various cancers, where it plays a role in mediating inflammatory responses and supporting tumor growth. The protein is secreted by various cell types, including macrophages, fibroblasts, and tumor cells, and its expression can be modulated by pro-inflammatory cytokines. Research on recombinant CHI3L1 has gained momentum due to its potential as a biomarker for disease diagnosis, prognosis, and therapeutic target. Studies have investigated its role in modulating immune responses, influencing cell proliferation, and promoting angiogenesis. Furthermore, recombinant CHI3L1 is being explored as a potential therapeutic agent, as its modulation may offer new avenues for treating inflammatory and cancerous conditions. Understanding its structure and function at a molecular level through recombinant protein studies could elucidate its complex biological roles and contribute to the development of novel therapeutic strategies. These insights may enable targeted interventions that could mitigate the adverse effects associated with elevated CHI3L1 levels, ultimately leading to enhanced patient outcomes in inflammatory and oncological diseases.
