Analytical Data
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基因名
GDF1
- Application
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别名
GDF1；Embryonic growth/differentiation factor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P27539
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表达区间
254-372aa
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氨基酸序列
DAEPVLG GGPGGACRAR RLYVSFREVG WHRWVIAPRG FLANYCQGQC ALPVALSGSG GPPALNHAVL RALMHAAAPG AADLPCCVPA RLSPISVLFF DNSDNVVLRQ YEDMVVDECG CR
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDF1 (Growth Differentiation Factor 1) is a member of the TGF-β superfamily, which plays a crucial role in various biological processes including embryonic development, organogenesis, and cellular differentiation. The significance of GDF1 in developmental biology has garnered attention due to its specific expression patterns during early embryogenesis and its implication in cardiac and neural development. Research indicates that GDF1 operates through the Smad signaling pathway, influencing gene expression patterns that are vital for proper organ formation. Moreover, studies have linked GDF1 to various pathologies, including congenital heart defects, emphasizing its potential as a therapeutic target. Recent advances have facilitated the production of recombinant GDF1 protein, allowing researchers to explore its functional properties and interactions in greater detail. This recombinant protein aids in elucidating the molecular mechanisms underlying GDF1's biological activities and its potential roles in disease. Understanding the structure-function relationship of GDF1 and its signaling pathways could unveil novel strategies for regenerative medicine and targeted therapies in developmental disorders and cardiovascular diseases, making it a significant focus in biomedical research.
