Analytical Data
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Gene name
NOV
- Application
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Alternative Names
NOV;IGFBP9;NOV;NOVH;CCN family member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48745
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Expression Region
28-357aa
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AA Sequence
M+QVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
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Molecular Weight
36.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NOV (Nephroblastoma Overexpressed) is a member of the CCN family of proteins, which are secreted signaling molecules involved in various cellular processes, including cell adhesion, proliferation, and differentiation. Initially identified for its overexpression in nephroblastoma, a type of kidney cancer, NOV has since attracted attention for its broader involvement in multiple biological functions and diseases. Research has shown that NOV plays a critical role in tissue development, wound healing, and fibrosis by modulating the interactions between cells and the extracellular matrix. Its dysregulation has been implicated in several pathological conditions, including cancer, cardiovascular diseases, and chronic inflammatory disorders. Due to its unique structural features, which include a cysteine-rich domain and several other functional motifs, NOV has drawn interest for its potential therapeutic applications. Understanding the mechanisms by which NOV mediates its effects on cellular behavior could lead to innovative treatment strategies for diseases characterized by aberrant cellular signaling. Furthermore, NOV's potential as a biomarker for disease progression and prognosis highlights the importance of continued research into its functional roles and regulatory pathways.











