Analytical Data
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基因名
PRSS12
- Application
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别名
PRSS12;Neurotrypsin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56730
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表达区间
631-874aa
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氨基酸序列
IIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTK
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分子量
43.4kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRSS12, also known as tumor-associated trypsinogen, is a serine protease that plays a crucial role in various physiological and pathological processes, particularly in cancer biology. Researchers have identified PRSS12 as a potential biomarker for several types of cancers due to its altered expression patterns in tumor tissues compared to normal tissues. As a serine protease, PRSS12 is involved in the activation of other proteolytic enzymes and signaling pathways, influencing cell proliferation, migration, and invasion—all critical factors in tumor development and progression. The study of PRSS12 has garnered attention for its potential to enhance our understanding of cancer mechanisms and for its utility in diagnostic and therapeutic applications. Recent advancements in recombinant protein technology have enabled the production of PRSS12 in significant quantities, facilitating detailed biochemical and structural studies. By investigating its enzymatic activity and substrate specificity, researchers aim to unravel the functional roles of PRSS12 in different cellular contexts. Furthermore, the development of PRSS12-targeted therapies could open new avenues for innovative cancer treatment strategies, focusing on disrupting its activity or mitigating its effects on tumor cell behavior. Given the critical implications of PRSS12 in tumor biology, ongoing research is essential to fully elucidate its role and therapeutic potential, paving the way for future clinical applications.












