Cat: PA1000-421DB

Recombinant Human CAPZA2 Protein,His

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Analytical Data

  • Gene name

    CAPZA2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CAPZA2;F-actin-capping Protein subunit alpha-2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P47755

  • Expression Region

    1-286aa

  • AA Sequence

    MGSSHHHHHH SSGLVPRGSH MGSMADLEEQ LSDEEKVRIA AKFIIHAPPG EFNEVFNDVR LLLNNDNLLR EGAAHAFAQY NLDQFTPVKI EGYEDQVLIT EHGDLGNGKF LDPKNRICFK FDHLRKEATD PRPCEVENAV ESWRTSVETA LRAYVKEHYP NGVCTVYGKK IDGQQTIIAC IESHQFQAKN FWNGRWRSEW KFTITPSTTQ VVGILKIQVH YYEDGNVQLV SHKDIQDSLT VSNEVQTAKE FIKIVEAAEN EYQTAISENY QTMSDTTFKA LRRQLPVTRT KIDWNKILSY KIGKEMQNA

  • Molecular Weight

    35 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CAPZA2, a member of the CAPZ protein family, plays a critical role in regulating actin dynamics by capping the barbed ends of actin filaments, thereby influencing cellular processes such as motility, shape, and division. Its function is vital in various biological contexts, including muscle development, neuronal signaling, and cell migration. Dysregulation of CAPZA2 has been linked to several diseases, such as cancer and neurodegenerative disorders, underscoring its potential as a therapeutic target. Research on CAPZA2 recombinant protein focuses on understanding its structure-function relationships and biochemical properties, enabling the exploration of its role in cellular behavior at the molecular level. Furthermore, recombinant CAPZA2 can serve as a valuable tool for biochemical assays and drug screening, facilitating the identification of novel modulators that can influence actin dynamics in disease contexts. Given the importance of actin filament regulation in numerous physiological and pathological processes, the study of CAPZA2 represents a promising avenue for uncovering fundamental insights into cellular mechanics and the development of innovative therapeutic strategies.

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