Analytical Data
-
Gene name
DBN1
- Application
-
Alternative Names
DBN1；D0S117E；Drebrin
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q16643
-
Expression Region
2-649aa
-
AA Sequence
AGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DBN1, or Dab1, is a protein that plays a critical role in neuronal development and signaling pathways, particularly in relation to the Reelin pathway, which is essential for proper brain architecture and function. Research on DBN1 has gained momentum due to its implications in various neurological disorders, including schizophrenia, autism spectrum disorders, and Alzheimer’s disease. The protein is involved in processes such as neuronal migration, synaptic plasticity, and cell signaling, making it a focal point in understanding the molecular underpinnings of neurodevelopmental and neurodegenerative diseases. Studies have demonstrated that DBN1 interacts with other key proteins in the signaling cascade, influencing synaptic development and maintenance. Furthermore, recombinant DBN1 protein has been utilized in various experimental settings to elucidate its functional role and mechanisms of action in neuronal contexts. The reconstitution of DBN1 through recombinant DNA technology allows researchers to produce large quantities of the protein for biochemical assays, providing insights into its structure-function relationships. As the field expands, understanding the precise mechanisms by which DBN1 contributes to neuronal health and pathology is critical for developing targeted therapeutic strategies to address the challenges posed by brain disorders linked to its dysfunction.
