Analytical Data
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基因名
EXOSC2
- Application
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别名
EXOSC2；RRP4；Exosome complex component RRP4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13868
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表达区间
1-293aa
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氨基酸序列
MAMEMRLPVA RKPLSERLGR DTKKHLVVPG DTITTDTGFM RGHGTYMGEE KLIASVAGSV ERVNKLICVK ALKTRYIGEV GDIVVGRITE VQQKRWKVET NSRLDSVLLL SSMNLPGGEL RRRSAEDELA MRGFLQEGDL ISAEVQAVFS DGAVSLHTRS LKYGKLGQGV LVQVSPSLVK RQKTHFHDLP CGASVILGNN GFIWIYPTPE HKEEEAGGFI ANLEPVSLAD REVISRLRNC IISLVTQRMM LYDTSILYCY EASLPHQIKD ILKPEIMEEI VMETRQRLLE QEG
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC2, a core component of the exonuclease complex involved in RNA metabolism, has gained significant attention in recent years due to its crucial role in the regulation of RNA stability and processing. As part of the exosome complex, EXOSC2 is implicated in various cellular processes, including the degradation of faulty or unwanted RNAs, thereby contributing to the maintenance of cellular RNA homeostasis. Abnormalities in EXOSC2 function have been associated with several diseases, including neurodegenerative disorders and certain types of cancer, highlighting its importance in human health. Recent studies have focused on the characterization of EXOSC2 recombinant protein to better understand its structural and functional properties. This includes investigating its interactions with other exosome components and substrate RNAs, as well as exploring its enzymatic activity. Understanding the mechanisms by which EXOSC2 operates can provide insights into RNA regulation and potentially reveal therapeutic targets for diseases linked to RNA metabolism dysregulation. The recombinant form of EXOSC2 serves not only as a tool for biochemical analyses but also as a candidate for developing novel strategies in gene therapy and molecular medicine. As research in this area progresses, it is expected that a deeper comprehension of EXOSC2 will pave the way for advancements in understanding RNA biology and the development of targeted therapies for RNA-related diseases.
