Analytical Data
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基因名
BECN1
- Application
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别名
BECN1；GT197；Beclin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14457
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表达区间
1-450aa
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氨基酸序列
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTA QAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLI GEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDT QLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELED VEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSV ENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELP LYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEK GKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
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分子量
78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BECN1 (Beclin 1) is a crucial protein involved in the regulation of autophagy, a cellular process responsible for degrading and recycling cellular components. It plays a significant role in various physiological and pathological processes, including development, immunity, and cancer. Research has shown that BECN1 is a vital component of the class III phosphatidylinositol 3-kinase (PI3K) complex, which initiates the formation of autophagosomes. Dysregulation of BECN1 is implicated in numerous diseases, particularly cancer, where it often functions as a tumor suppressor. Because of its central role in autophagy and cell survival, BECN1 has emerged as a potential therapeutic target for cancer treatment and neurodegenerative diseases. Recent studies have focused on the structural and functional analysis of BECN1, emphasizing the importance of its interactions with other proteins and lipids. The recombinant expression of BECN1 provides a platform for elucidating its molecular mechanisms and potential as a drug target. Understanding BECN1's role in autophagy and its implications in disease could pave the way for novel therapeutic strategies aimed at manipulating this pathway for clinical benefit. As research advances, the role of BECN1 in both promoting and inhibiting autophagy highlights its complexity and the need for further investigation into its multifaceted functions within cells.
