Analytical Data
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Gene name
RRM2B
- Application
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Alternative Names
TP53-inducible ribonucleotide reductase M2 B p53-inducible ribonucleotide reductase small subunit 2-like protein
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7LG56
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Expression Region
1-351aa
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Molecular Weight
67.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RRM2B, a critical component of the ribonucleotide reductase complex, plays a vital role in DNA synthesis and repair by regulating the conversion of ribonucleotides into deoxyribonucleotides, which are essential for DNA replication and cellular proliferation. Mutations in the RRM2B gene have been linked to a range of human diseases, including mitochondrial disorders and certain types of cancer, highlighting its importance in maintaining genomic stability. The study of RRM2B recombinant proteins has gained significant attention in the fields of molecular biology and biochemistry, as understanding its structure and function can provide insights into the mechanisms underlying DNA metabolism and cellular responses to oxidative stress. Through the expression and characterization of RRM2B recombinant proteins, researchers aim to elucidate its enzymatic properties, interaction with other cellular components, and potential regulatory pathways, ultimately contributing to the development of novel therapeutic strategies targeting RRM2B-related conditions. Advances in recombinant protein technology and analytical techniques enable detailed investigation of RRM2B, stressing its relevance in both basic research and clinical applications.
