Analytical Data
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Gene name
Dsg1a
- Application
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Alternative Names
DG1 (DGI) (Desmosomal glycoprotein I) (Desmoglein-1) (Dsg1-alpha) (Dsg1)
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Species
Mouse
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q61495
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Expression Region
50-564aa
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Molecular Weight
77.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dsg1a (Desmoglein 1a) is a critical member of the desmosome protein family, which plays a vital role in maintaining cell adhesion and epidermal integrity in human skin. Mutations or dysregulation of Dsg1a are associated with various skin disorders, such as pemphigus foliaceus and other autoimmune diseases. The recombinant production of Dsg1a has garnered significant interest in recent years, as it provides an opportunity to study its structure, function, and interactions with other cellular components in vitro. Researchers aim to understand the molecular mechanisms underlying desmosomal adhesion and the pathogenesis of related diseases by generating Dsg1a in a recombinant system. The purified protein can be used for biochemical assays, structural determination, and the development of therapeutic strategies. Moreover, producing Dsg1a in a heterologous expression system can facilitate the investigation of protein folding, post-translational modifications, and potential functional assays, advancing our understanding of its role in epidermal cell biology and disease. As the field evolves, the focus is also shifting towards potential applications in regenerative medicine and targeted therapies that leverage the unique properties of desmosome proteins, highlighting the importance of Dsg1a research in both basic and translational science.
