Analytical Data
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基因名
SOCS2
- Application
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别名
SOCS2；CIS2；SSI2；STATI2；Suppressor of cytokine signaling 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14508
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表达区间
1-198aa
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氨基酸序列
MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYW GSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQ DGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHL YLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV
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分子量
49 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOCS2 (Suppressor of Cytokine Signaling 2) is a member of the SOCS family, which plays a crucial role in regulating cytokine signaling pathways and maintaining immune homeostasis. It acts as a negative feedback regulator for various cytokines, including growth hormone, leptin, and interleukins, thus influencing critical physiological processes such as metabolism, growth, and inflammation. Aberrant SOCS2 expression has been linked to several diseases, including obesity, metabolic disorders, and cancers, making it a significant target for therapeutic intervention. The reconstitution of SOCS2 protein offers the potential for extensive research into its structural and functional characteristics, enabling insights into its specific mechanisms of action. This recombinant protein can be utilized in various experimental settings to study its interactions with other signaling molecules, assess its role in immune response modulation, and investigate its potential as a therapeutic agent in conditions associated with SOCS2 dysregulation. Understanding the functional role of SOCS2 through recombinant protein studies is essential for developing effective strategies to harness its signaling pathways for therapeutic purposes.
