Analytical Data
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基因名
MEPE
- Application
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别名
MEPE；Matrix extracellular phosphoglycoProtein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQ76
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表达区间
18-525aa
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氨基酸序列
PTF QPQTEKTKQS CVEEQRQEEK NKDNIGFHHL GKRINQELSS KENIVQERKK DLSLSEASEN KGSSKSQNYF TNRQRLNKEY SISNKENTHN GLRMSIYPKS TGNKGFEDGD DAISKLHDQE EYGAALIRNN MQHIMGPVTA IKLLGEENKE NTPRNVLNII PASMNYAKAH SKDKKKPQRD SQAQKSPVKS KSTHRIQHNI DYLKHLSKVK KIPSDFEGSG YTDLQERGDN DISPFSGDGQ PFKDIPGKGE ATGPDLEGKD IQTGFAGPSE AESTHLDTKK PGYNEIPERE ENGGNTIGTR DETAKEADAV DVSLVEGSND IMGSTNFKEL PGREGNRVDA GSQNAHQGKV EFHYPPAPSK EKRKEGSSDA AESTNYNEIP KNGKGSTRKG VDHSNRNQAT LNEKQRFPSK GKSQGLPIPS RGLDNEIKNE MDSFNGPSHE NIITHGRKYH YVPHRQNNST RNKGMPQGKG SWGRQPHSNR RFSSRRRDDS SESSDSGSSS ESDGD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MEPE (Matrix Extracellular Phosphoglycoprotein) is an important biomarker implicated in bone metabolism and mineralization and is primarily expressed in osteoblasts and osteocytes. It is known to play a crucial role in regulating phosphate homeostasis and may contribute to the pathological processes associated with bone diseases such as osteoporosis and osteomalacia. Research into MEPE has gained momentum due to its complex involvement in skeletal development and remodeling, as well as its potential interactions with other bone matrix proteins and signaling pathways. The restructured protein forms of MEPE offer insights into its functional domains and regulatory mechanisms, allowing scientists to explore its therapeutic potential. Understanding the structure-function relationship of MEPE can lead to novel approaches in the treatment of bone disorders, enhancing our knowledge of bone-related pathologies and paving the way for innovative interventions in bone health and regeneration. The ongoing studies on MEPE's post-translational modifications, its interaction with various growth factors, and its role in osteoblast-osteoclast crosstalk represent a frontier in bone biology research, highlighting its significance in both fundamental science and clinical applications.
