Analytical Data
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Gene name
ARHGEF39
- Application
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Alternative Names
ARHGEF39；C9orf100；Rho guanine nucleotide exchange factor 39
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N4V3
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Expression Region
1-335aa
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AA Sequence
MELSCPGSRC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFLG ILKAKGTLRP PERQALFGSW ELIYGASQEL LPYLEGGCWG QGLEGFCRHL ELYNQFAANS ERSQTTLQEQ LKKNKGFRRF VRLQEGRPEF GGLQLQDLLP LPLQRLQQYE NLVVALAENT GPNSPDHQQL TRAARLISET AQRVHTIGQK QKNDQHLRRV QALLSGRQAK GLTSGRWFLR QGWLLVVPPH GEPRPRMFFL FTDVLLMAKP RPPLHLLRSG TFACKALYPM AQCHLSRVFG HSGGPCGGLL SLSFPHEKLL LMSTDQEELS RWYHSLTWAI SSQKN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARHGEF39, a member of the Rho guanine nucleotide exchange factor (GEF) family, plays a critical role in regulating small GTPases, particularly Rho and Rac proteins, which are essential for various cellular processes, including cytoskeletal organization, cell migration, and cell cycle progression. Recent studies have highlighted its involvement in several physiological and pathological contexts, such as cancer progression, cardiovascular diseases, and neuronal development. Given the significance of Rho GTPases in signal transduction pathways, there is increasing interest in understanding the molecular mechanisms by which ARHGEF39 exerts its effects. This includes characterizing the protein's structure, identifying its interacting partners, and elucidating its regulatory role in cellular signaling. Recombinant proteins of ARHGEF39 serve as valuable tools for these studies, enabling researchers to dissect its functionality in vitro and in vivo. Understanding ARHGEF39’s action and its broader implications in health and disease could pave the way for novel therapeutic strategies targeting Rho GTPase signaling pathways, making it a compelling subject for further investigation in both basic and applied biosciences.
