Analytical Data
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Gene name
AP3S1
- Application
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Alternative Names
AP3S1；CLAPS3；AP-3 complex subunit sigma-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62368
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Expression Region
1-193aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP3S1, a gene encoding the small subunit of the adaptor protein complex 3 (AP-3), plays a crucial role in intracellular trafficking and the sorting of proteins to lysosomes and lysosome-related organelles. Research on AP3S1 is significant due to its implications in various cellular processes and potential links to disease. Mutations in AP3S1 have been associated with hereditary diseases, such as Hermansky-Pudlak syndrome, a condition characterized by oculocutaneous albinism, bleeding disorders, and immunodeficiency. Understanding AP3S1 is essential for elucidating the mechanisms of protein transport and sorting, which are vital for maintaining cellular homeostasis. Recent studies have focused on the structural characterization of AP3S1 and its interactions with other components of the AP-3 complex, enhancing our understanding of its functional role in endosomal pathways. Furthermore, investigating the impact of AP3S1 mutations can provide insights into the pathogenesis of related disorders, highlighting the importance of this protein in both normal physiology and disease states.
