Analytical Data
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Gene name
PABPC4
- Application
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Alternative Names
PABP-4 (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) (APP1) (PABP4)
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13310
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Expression Region
1-644aa
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Molecular Weight
70.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PABPC4, or Polyadenylate Binding Protein Cytoplasmic 4, is a member of the poly(A)-binding protein family known for its role in regulating mRNA metabolism, including translation, stability, and localization. The study of PABPC4 has gained significant attention due to its potential implications in various biological processes and diseases, particularly in cancer and neurodegenerative disorders. Research indicates that PABPC4 may play a role in the regulation of gene expression and cellular stress responses, impacting cell proliferation and survival. This protein's interactions with RNA and other cellular components suggest it could be a crucial factor in post-transcriptional regulation. Understanding the structure and function of recombinant PABPC4 can provide insights into its biological roles and mechanisms, making it a target for therapeutic interventions. Furthermore, purifying and characterizing PABPC4 as a recombinant protein allows researchers to investigate its biochemical properties and interaction partners in detail. This exploration is essential for elucidating the protein’s functions in cellular contexts and may uncover new pathways for regulation and potential therapeutic strategies in treating diseases associated with dysregulated mRNA metabolism. Overall, the research on recombinant PABPC4 not only enhances our understanding of fundamental biological processes but also has significant implications for advancing targeted therapies in various diseases.
