Analytical Data
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基因名
AMPD2
- Application
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别名
AMPD2；AMP deaminase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01433
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表达区间
236-879aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSDLLDAAKSVVRALFIREKYMALSLQSF CPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEP STMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVL MALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNI RKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFES MNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNR VSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHR VHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHP ELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYY TFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLL LRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLS TDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVK SHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQELALITQAVQSEM LETIPEEAGITMSPGPQ
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分子量
77 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AMPD2, or adenosine monophosphate deaminase 2, is a crucial enzyme involved in the purine nucleotide breakdown pathway, converting AMP to IMP and thereby regulating cellular energy levels and nucleotide pool balance. Research on AMPD2 has garnered attention due to its potential implications in various physiological and pathological processes, including muscle metabolism, cancer progression, and cardiovascular diseases. Mutations or dysregulation of AMPD2 have been linked to certain inherited metabolic disorders, particularly in skeletal muscle, leading to exercise intolerance and muscle weakness. Furthermore, studies have suggested that AMPD2 might influence cellular responses to stress and apoptosis, highlighting its role in cell survival. The recombinant expression of AMPD2 allows for detailed structural and functional studies, providing insights into its enzymatic mechanisms and interactions with other biomolecules. By characterizing the recombinant protein, researchers aim to elucidate the enzyme's role in health and disease, potentially leading to novel therapeutic strategies targeting metabolic disorders or enhancing muscle performance. Understanding AMPD2's functions at a molecular level could pave the way for advancements in treatments for conditions associated with energy metabolism and muscle function.
