Analytical Data
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基因名
AMD1
- Application
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别名
AMD1；AMP deaminase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17707
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表达区间
68-334aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMSSMFV SKRRFILKTC GTTLLLKALV PLLKLARDYS GFDSIQSFFY SRKNFMKPSH QGYPHRNFQE EIEFLNAIFP NGAAYCMGRM NSDCWYLYTL DFPESRVISQ PDQTLEILMS ELDPAVMDQF YMKDGVTAKD VTRESGIRDL IPGSVIDATM FNPCGYSMNG MKSDGTYWTI HITPEPEFSY VSFETNLSQT SYDDLIRKVV EVFKPGKFVT TLFVNQSSKC RTVLASPQKI EGFKRLDCQS AMFNDYNFVF TSFAKKQQQQ QS
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of AMD1 recombinant proteins is significant due to their crucial role in cellular metabolism, particularly in the regulation of polyamine biosynthesis. AMD1, or Adenosine Monophosphate Deaminase 1, is an enzyme that catalyzes the conversion of adenosine monophosphate (AMP) to inosine monophosphate (IMP), a critical precursor in the synthesis of nucleotides. Alterations in the activity of AMD1 have been linked to various pathological conditions, including cancer, where aberrant polyamine metabolism can promote tumor growth and development. As researchers strive to understand the molecular mechanisms behind these diseases, AMD1 has emerged as a potential therapeutic target. Recombinant protein technology allows for the expression and purification of AMD1, facilitating detailed studies into its structure, function, and interactions with other cellular components. By characterizing AMD1 through recombinant approaches, scientists aim to uncover its regulatory pathways and potential as a biomarker or target in therapeutic interventions. The insights gained from these studies can lead to novel strategies for cancer treatment and better understanding of metabolic disorders, highlighting the importance of AMD1 in both health and disease.
