Analytical Data
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Gene name
FGFR-2
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简介
FGFR2, also known as CD332 (differentiated cluster 332), is a receptor for fibroblast growth factor. FGFR2 is involved in activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR2 up-regulates PAI-1 via JAK2/STAT3 signaling and induces M2 polarization in colorectal cancer macrophages. FGFR-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
E9Q5C3
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Expression Region
R22-E263
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Protein Length
Partial
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Molecular Weight
89.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 2 (FGFR-2) is a crucial member of the fibroblast growth factor receptor family, playing significant roles in various physiological processes, including cell proliferation, differentiation, and survival. Dysregulation of FGFR-2 signaling has been implicated in several cancers, particularly breast and gastric cancers, making it a target of interest for therapeutic interventions. As a result, the development of recombinant FGFR-2 proteins has gained importance in the field of biomedical research. These recombinant proteins serve as essential tools for studying the receptor's structure and function, particularly in understanding the mechanisms of ligand-receptor interactions and downstream signaling pathways. Additionally, FGFR-2 recombinant proteins are valuable in drug discovery efforts, helping to facilitate the development of FGFR-targeted therapies such as small molecule inhibitors and monoclonal antibodies. Research on FGFR-2 has broadened to include its potential implications in regenerative medicine and the treatment of congenital disorders linked to FGFR mutations. Overall, the study of FGFR-2 recombinant proteins not only enhances our understanding of its biological significance but also contributes to the advancement of novel therapeutic strategies aimed at combating diseases associated with FGFR-2 dysregulation.
